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    Gynecological symptoms

    Endometriosis is a chronic inflammatory condition with a wide variety of symptoms that can present differently in adolescents compared to adults. These symptoms can include dysmenorrhea (painful menstruation), non-menstrual pelvic pain, pain during or after sexual intercourse (deep dyspareunia), and heavy menstrual bleeding. Recognizing these symptoms in adolescents can be challenging, as they may be considered as classic menstrual pain. It is important to not overlook persisting symptoms, especially if they do not improve with first-line treatment. The pathophysiology of pelvic pain in endometriosis involves complex mechanisms both in the peripheral and central nervous systems.

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    Understanding Endometriosis in Adolescents: Challenges, Symptoms, and Pathophysiology

    Endometriosis is a chronic inflammatory condition primarily affecting pelvic structures, but its manifestations can be diverse and complex. The heterogeneity of symptoms and the lack of correlation between symptom severity and the disease's staging make endometriosis particularly challenging to diagnose and manage, especially in adolescent patients.

    The Complexity of Endometriosis Symptoms

    Endometriosis can present with a wide array of symptoms, and notably, there is no direct link between the severity of symptoms reported by patients and the stage of the disease according to classifications like the American Fertility Society (AFS) or the American Society of Reproductive Medicine (ASRM). Some women may experience debilitating symptoms, while others might be asymptomatic, or present with a mix of mild to severe symptoms that do not necessarily correspond to the extent of the disease observed during surgery. Additionally, the areas of pain described by patients do not always align with the locations of endometriotic lesions, further complicating diagnosis and treatment.

    Diagnostic Challenges in Adolescents

    Recognizing endometriosis in adolescents is particularly challenging. This difficulty is compounded by the widespread misconception that menstrual pain is normal, along with societal stigma surrounding gynecological issues. As a result, adolescents are often misunderstood, and their symptoms may be minimized or dismissed, leading to significant delays in diagnosis—on average, it takes between 6 to 12 years to correctly diagnose endometriosis.

    Adolescents typically present with painful symptoms, such as dysmenorrhea (painful menstruation), while infertility, a common concern in adult women with endometriosis, is rarely observed in this younger population. It has been hypothesized that endometriosis in adolescents may be more aggressive and present with a broader range of symptoms than in adults, making early recognition and intervention critical.

    Dysmenorrhea in Adolescents: A Common but Overlooked Symptom

    Dysmenorrhea is one of the most commonly reported symptoms of endometriosis in adolescents. However, it is essential to differentiate between primary dysmenorrhea, which occurs in the absence of pelvic pathology and is often due to high levels of prostaglandins and leukotrienes, and secondary dysmenorrhea, which can result from conditions like endometriosis, adenomyosis, infections, or other pelvic pathologies.

    In some cases, dysmenorrhea can be so severe that it leads to absenteeism from school or other activities. An Italian survey found that 12% of adolescents miss school or work each month due to severe menstrual pain. When dysmenorrhea persists despite treatment with hormonal agents and nonsteroidal anti-inflammatory drugs (NSAIDs), and no other underlying cause is identified, endometriosis should be considered, particularly if risk factors are present.

    Non-Menstrual Pelvic Pain and Chronic Pain in Adolescents

    Beyond dysmenorrhea, adolescents with endometriosis may experience non-menstrual pelvic pain, which can become chronic if it lasts for six months or longer. This pain can be constant, intermittent, cyclic, or acyclic. Research indicates that nearly two-thirds of adolescents with chronic acyclic pain or persistent dysmenorrhea who undergo laparoscopy are found to have endometriosis. Furthermore, an Italian survey reported that 13% of adolescents with endometriosis experience inter-menstrual pelvic pain severe enough to disrupt their daily activities.

    Interestingly, while it was previously believed that dysmenorrhea was the primary symptom of endometriosis in adolescents, recent evidence suggests that only 9% of adolescents with diagnosed endometriosis present with classic dysmenorrhea. Instead, 62% report both cyclic and non-cyclic pain, with nearly one-third experiencing isolated non-cyclic pain. These findings highlight the need for clinicians to consider a broader spectrum of symptoms when evaluating adolescents for endometriosis.

    The Impact of Early-Onset Pain and Sensitization

    There is no significant difference between the severity of dysmenorrhea and chronic pelvic pain in adolescents and adults, although adolescents are more likely to report an earlier onset of pain, often starting at menarche. Repeated episodes of acute dysmenorrhea shortly after menarche may not only signal the presence of endometriosis or adenomyosis but may also contribute to the development of chronic pelvic pain. This transition from acute to chronic pain is a critical area of concern, as it may lead to peripheral and central sensitization, making the pain more difficult to manage over time.

    Dyspareunia and Heavy Menstrual Bleeding

    Another symptom that emerges in older adolescents (17-19 years of age) is deep dyspareunia, or pain during or after sexual intercourse. This symptom affects 27% of sexually active adolescents with endometriosis and is more prevalent in older adolescents. The longer the delay in diagnosing endometriosis, the more likely it is for pain to become chronic, leading to sensitization and worsening of symptoms.

    Heavy menstrual bleeding is also frequently reported by adolescents with endometriosis. However, it remains debated whether this symptom is directly caused by endometriosis or if it is due to concomitant conditions like adenomyosis, which is present in up to 90% of patients diagnosed with endometriosis.

    The Complex Pathophysiology of Endometriosis-Related Pain

    The pain associated with endometriosis is multifaceted and involves both peripheral and central mechanisms. Studies suggest that a combination of peripheral pain sensitizers, such as chemokines and cytokines found in peritoneal fluid, may contribute to the pain experienced by women with endometriosis. Additionally, central sensitization mechanisms—including structural changes in the brain, alterations in the autonomic nervous system, and changes in the body’s response to painful stimuli—are believed to play a role in the chronic pain associated with endometriosis.

    Conclusion

    Endometriosis in adolescents is a complex and often misunderstood condition. The diverse and sometimes ambiguous symptoms, coupled with a significant diagnostic delay, make it crucial for clinicians to maintain a high index of suspicion, particularly in young patients presenting with persistent or severe dysmenorrhea, non-menstrual pelvic pain, or other related symptoms. Early recognition and intervention are key to managing this chronic condition and improving the quality of life for affected adolescents.